Journal
SCIENCE CHINA-CHEMISTRY
Volume 53, Issue 9, Pages 1899-1906Publisher
SCIENCE PRESS
DOI: 10.1007/s11426-010-4036-6
Keywords
asymmetric hydrovinylation; chiral spiro phosphorus ligands; functionalized olefins; chiral quaternary center
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Funding
- National Natural Science Foundation of China
- National Basic Research Program of China (973 Program) [2006CB806106, 2010CB833300]
- Ministry of Health [2009ZX09501-017]
- Ministry of Education of China [B06005]
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Asymmetric hydrovinylation of silyl-protected allylic alcohols catalyzed by nickel complexes of chiral spiro phosphoramidite ligands was developed. A series of homoallylic alcohols with a chiral quaternary center were produced in high yields (up to 97%) and high enantioselectivities (up to 95% ee). The reaction provides an efficient method for preparing bifunctional compounds with a chiral quaternary carbon center.
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