4.6 Article

An odorless thia-Michael addition using Bunte salts as thiol surrogates

Journal

RSC ADVANCES
Volume 5, Issue 34, Pages 27107-27111

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ra01381j

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Funding

  1. Chinese National Natural Science Foundation [21402093, 21476116]
  2. Jiangsu Province Natural Science Foundation [BK20140776, BK20141394]

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A newly developed C-S bond formation process via acid-catalyzed thia-Michael addition has been demonstrated. The protocol, in which Bunte salts generated from odorless, inexpensive sodium thiosulfate and organic halides are used as the thiol precursors, provides an efficient approach for the synthesis of beta-sulfido carbonyl compounds.

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