Journal
SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS
Volume 14, Issue 5, Pages -Publisher
NATL INST MATERIALS SCIENCE
DOI: 10.1088/1468-6996/14/5/054402
Keywords
paper-based microfluidics; biosensors; electrochemical detection; multiplexing; metabolic markers; disease diagnostics
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Funding
- Grand Challenge Canada (through a Star in Global Health Award)
- Natural Sciences and Engineering Research Council of Canada
- Canadian Foundation for Innovation
- Canadian Research Chairs Program
- McGill University
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Paper-based microfluidic devices have emerged as simple yet powerful platforms for performing low-cost analytical tests. This paper reports a microfluidic paper-based electrochemical biosensor array for multiplexed detection of physiologically relevant metabolic biomarkers. Different from existing paper-based electrochemical devices, our device includes an array of eight electrochemical sensors and utilizes a handheld custom-made electrochemical reader (potentiostat) for signal readout. The biosensor array can detect several analytes in a sample solution and produce multiple measurements for each analyte from a single run. Using the device, we demonstrate simultaneous detection of glucose, lactate and uric acid in urine, with analytical performance comparable to that of the existing commercial and paper-based platforms. The paper-based biosensor array and its electrochemical reader will enable the acquisition of high-density, statistically meaningful diagnostic information at the point of care in a rapid and cost-efficient way.
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