Journal
SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS
Volume 14, Issue 5, Pages -Publisher
NATL INST MATERIALS SCIENCE
DOI: 10.1088/1468-6996/14/5/055009
Keywords
mesoporous calcium silicate; magnetic hyperthermia; drug delivery; bone regeneration
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Funding
- Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning
- National Natural Science Foundation of China [51102166]
- Program for New Century Excellent Talent in University [NCET-12-1053]
- Chinese Ministry of Education [212055]
- Shanghai Pujiang Program [11PJ1407300]
- Shanghai Shuguang Project [12SG39]
- Shanghai Municipal Education Commission [12ZZ140]
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We have prepared multifunctional magnetic mesoporous Fe-CaSiO3 materials using triblock copolymer (P123) as a structure-directing agent. The effects of Fe substitution on the mesoporous structure, in vitro bioactivity, magnetic heating ability and drug delivery property of mesoporous CaSiO3 materials were investigated. Mesoporous Fe-CaSiO3 materials had similar mesoporous channels (5-6 nm) with different Fe substitution. When 5 and 10% Fe were substituted for Ca in mesoporous CaSiO3 materials, mesoporous Fe-CaSiO3 materials still showed good apatite-formation ability and had no cytotoxic effect on osteoblast-like MC3T3-E1 cells evaluated by the elution cell culture assay. On the other hand, mesoporous Fe-CaSiO3 materials could generate heat to raise the temperature of the surrounding environment in an alternating magnetic field due to their superparamagnetic property. When we use gentamicin (GS) as a model drug, mesoporous Fe-CaSiO3 materials release GS in a sustained manner. Therefore, magnetic mesoporous Fe-CaSiO3 materials would be a promising multifunctional platform with bone regeneration, local drug delivery and magnetic hyperthermia.
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