Journal
SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS
Volume 12, Issue 4, Pages -Publisher
NATL INST MATERIALS SCIENCE
DOI: 10.1088/1468-6996/12/4/044607
Keywords
neutron capture therapy; GdNCT; fullerene; Gd@C-82; PEG-b-polyamine; in vitro
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Funding
- Inter-University Program for the Joint Use of JAEA Facilities
- Japan Society for the Promotion of Science
- Grants-in-Aid for Scientific Research [22659008, 20106011, 21240050] Funding Source: KAKEN
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Poly(ethylene glycol)-block-poly(2-(N,N-diethylamino)ethyl methacrylate) (PEG-b-PAMA) was found to solubilize fullerenes such as C-60, and this technique was applied to metallofullerenes. Gd@C-82 was easily dissolved in water in the presence of PEG-b-PAMA without any covalent derivatization, forming a transparent complex about 20-30 nm in diameter. Low cytotoxicity was confirmed in vitro. Neutron irradiation of cultured cells (colon-26 adenocarcinoma) with Gd@C-82-PEG-b-PAMA-complexed nanoparticles showed effective cytotoxicity, indicating the effective emission of gamma rays and internal conversion electrons produced from the neutron capture reaction of Gd. This result suggests a potentially valuable approach to gadolinium-based neutron capture therapy.
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