Journal
SCIENCE
Volume 343, Issue 6166, Pages 91-94Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1244724
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Funding
- National Institute for Basic Biology Priority Collaborative Research Project [10-104]
- Cell Science Research Foundation
- Comprehensive Brain Science Network
- [23300115]
- Grants-in-Aid for Scientific Research [20247005, 13J08781, 22132007, 25440166, 24657148, 23300115, 12J04521, 26221104, 24657050, 12J05418, 25251034] Funding Source: KAKEN
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Social familiarity affects mating preference among various vertebrates. Here, we show that visual contact of a potential mating partner before mating (visual familiarization) enhances female preference for the familiarized male, but not for an unfamiliarized male, in medaka fish. Terminal-nerve gonadotropin-releasing hormone 3 (TN-GnRH3) neurons, an extrahypothalamic neuromodulatory system, function as a gate for activating mating preferences based on familiarity. Basal levels of TN-GnRH3 neuronal activity suppress female receptivity for any male (default mode). Visual familiarization facilitates TN-GnRH3 neuron activity (preference mode), which correlates with female preference for the familiarized male. GnRH3 peptides, which are synthesized specifically in TN-GnRH3 neurons, are required for the mode-switching via self-facilitation. Our study demonstrates the central neural mechanisms underlying the regulation of medaka female mating preference based on visual social familiarity.
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