Journal
SCIENCE
Volume 343, Issue 6177, Pages 1363-1366Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1248725
Keywords
-
Categories
Funding
- Foundation for Polish Science (Fundacja na rzecz Nauki Polskiej)
- EU
- Deutsche Forschungsgemeinschaft Collaborative Research Center [803]
- European Research Council (ERC) [282008]
Ask authors/readers for more resources
The 18-kilodalton translocator protein TSPO is found in mitochondrial membranes and mediates the import of cholesterol and porphyrins into mitochondria. In line with the role of TSPO in mitochondrial function, TSPO ligands are used for a variety of diagnostic and therapeutic applications in animals and humans. We present the three-dimensional high-resolution structure of mammalian TSPO reconstituted in detergent micelles in complex with its high-affinity ligand PK11195. The TSPO-PK11195 structure is described by a tight bundle of five transmembrane alpha helices that form a hydrophobic pocket accepting PK11195. Ligand-induced stabilization of the structure of TSPO suggests a molecular mechanism for the stimulation of cholesterol transport into mitochondria.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available