Journal
SCIENCE
Volume 345, Issue 6192, Pages 90-94Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1251487
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Funding
- National Basic Research Program of China [2012CB945102, 2013CB945302]
- National Natural Science Foundation of China [91339104, 31271552, 31222038, 31301188]
- Chinese Academy of Sciences [KSCX2-EW-R-09]
- Shanghai Pujiang Program [11PJ1411400]
- Basic Research Key Project [14JC1407400]
- Organization Department of the CPC Central Committee Bajian Talents Program
- AstraZeneca
- Sanofi-Aventis Shanghai Institutes for Biological Sciences (SA-SIBS) Fellowship
- NIH [2 R01 HL094683]
- American Heart Association Established Investigator Award
- [SIBS-2013KIP311]
- [2013M541561]
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The postnatal coronary vessels have been viewed as developing through expansion of vessels formed during the fetal period. Using genetic lineage tracing, we found that a substantial portion of postnatal coronary vessels arise de novo in the neonatal mouse heart, rather than expanding from preexisting embryonic vasculature. Our data show that lineage conversion of neonatal endocardial cells during trabecular compaction generates a distinct compartment of the coronary circulation located within the inner half of the ventricular wall. This lineage conversion occurs within a brief period after birth and provides an efficient means of rapidly augmenting the coronary vasculature. This mechanism of postnatal coronary vascular growth provides avenues for understanding and stimulating cardiovascular regeneration following injury and disease.
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