Journal
SCIENCE
Volume 346, Issue 6206, Pages 237-241Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.346.6206.237
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Funding
- Swedish Research Council
- Swedish Cancer Society
- Karolinska Institute
- Tobias Stiftelsen
- The Swedish Heart and Lung Foundation
- StratRegen
- StemTherapy
- European Union [279017]
- Torsten Soderbergs Stiftelse
- Knut och Alice Wallenbergs Stiftelse
- Portuguese government [SFRH/BD/63164/2009]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/63164/2009] Funding Source: FCT
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Neurogenesis is restricted in the adult mammalian brain; most neurons are neither exchanged during normal life nor replaced in pathological situations. We report that stroke elicits a latent neurogenic program in striatal astrocytes in mice. Notch1 signaling is reduced in astrocytes after stroke, and attenuated Notch1 signaling is necessary for neurogenesis by striatal astrocytes. Blocking Notch signaling triggers astrocytes in the striatum and the medial cortex to enter a neurogenic program, even in the absence of stroke, resulting in 850 +/- 210 (mean +/- SEM) new neurons in a mouse striatum. Thus, under Notch signaling regulation, astrocytes in the adult mouse brain parenchyma carry a latent neurogenic program that may potentially be useful for neuronal replacement strategies.
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