Journal
SCIENCE
Volume 343, Issue 6167, Pages 200-204Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1247521
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Funding
- Medical Research Council Next Generation Optical Microscopy Award [MR/K015869/1]
- Wellcome Trust [083611/Z/07/Z]
- MRC [MR/K015869/1] Funding Source: UKRI
- Wellcome Trust [083611/Z/07/Z] Funding Source: Wellcome Trust
- Medical Research Council [MR/K015869/1] Funding Source: researchfish
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Withdrawal of differentiating cells from proliferative tissue is critical for embryonic development and adult tissue homeostasis; however, the mechanisms that control this cell behavior are poorly understood. Using high-resolution live-cell imaging in chick neural tube, we uncover a form of cell subdivision that abscises apical cell membrane and mediates neuron detachment from the ventricle. This mechanism operates in chick and mouse, is dependent on actin-myosin contraction, and results in loss of apical cell polarity. Apical abscission also dismantles the primary cilium, known to transduce sonic-hedgehog signals, and is required for expression of cell-cycle-exit gene p27/Kip1. We further show that N-cadherin levels, regulated by neuronal-differentiation factor Neurog2, determine cilium disassembly and final abscission. This cell-biological mechanism may mediate such cell transitions in other epithelia in normal and cancerous conditions.
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