Journal
RSC ADVANCES
Volume 5, Issue 42, Pages 32990-32993Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ra03849a
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Funding
- National Natural Science Foundation of China [21402085, 21102086, 21472118]
- Guangdong Provincial Department of Science and Technology of China [2012B050100007]
- Shanxi Province Science Foundation for Youths [2012021009-4, 2013011011-1]
- Shanxi Province Foundation for Returnee [2012-007]
- Shanxi Province Outstanding Youth Fund [2014021002]
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A novel 1,8-naphthalimide derivative bearing 3-amino and 6-(2,4-dinitrobenzenesulfonamido) groups was synthesized and found to exhibit a fluorescent turn-on response to biothiols, including Cys, Hcy and GSH. This compound exhibited high selectivity and low detection limit, in particular toward Cys. The sensing mechanism involved the cleavage of the 2,4-dinitrobenzenesulfonamido group and the formation of an electron-donating amino group. In addition, its properties for cellular imaging were also briefly discussed.
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