Journal
SCIENCE
Volume 342, Issue 6156, Pages 373-377Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1241224
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Funding
- NIH/National Institute of Neurological Disorders and Stroke [NS078167, NS078304, NS028642]
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The conservation of sleep across all animal species suggests that sleep serves a vital function. We here report that sleep has a critical function in ensuring metabolic homeostasis. Using real-time assessments of tetramethylammonium diffusion and two-photon imaging in live mice, we show that natural sleep or anesthesia are associated with a 60% increase in the interstitial space, resulting in a striking increase in convective exchange of cerebrospinal fluid with interstitial fluid. In turn, convective fluxes of interstitial fluid increased the rate of beta-amyloid clearance during sleep. Thus, the restorative function of sleep may be a consequence of the enhanced removal of potentially neurotoxic waste products that accumulate in the awake central nervous system.
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