Journal
SCIENCE
Volume 340, Issue 6129, Pages 211-216Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1232437
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Funding
- NIH
- National Institute of Neurological Disorders and Stroke, NIH [R01NS081707]
- National Institute on Drug Abuse, NIH [R00DA025182]
- McDonnell Center for Systems Neuroscience
- National Security Science and Engineering Faculty Fellowship of Energy
- Division of Materials Sciences, U.S. Department of Energy [DE-FG02-07ER46471]
- Materials Research Laboratory
- Center for Microanalysis of Materials [DE-FG02-07ER46453]
- Division of Biology and Biomedical Sciences, Washington University in St. Louis (WUSTL)
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Successful integration of advanced semiconductor devices with biological systems will accelerate basic scientific discoveries and their translation into clinical technologies. In neuroscience generally, and in optogenetics in particular, the ability to insert light sources, detectors, sensors, and other components into precise locations of the deep brain yields versatile and important capabilities. Here, we introduce an injectable class of cellular-scale optoelectronics that offers such features, with examples of unmatched operational modes in optogenetics, including completely wireless and programmed complex behavioral control over freely moving animals. The ability of these ultrathin, mechanically compliant, biocompatible devices to afford minimally invasive operation in the soft tissues of the mammalian brain foreshadow applications in other organ systems, with potential for broad utility in biomedical science and engineering.
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