Journal
SCIENCE
Volume 340, Issue 6132, Pages 595-599Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1233936
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Funding
- BBSRC [BB/G008833/1]
- EPSRC
- Wellcome University Award
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [943383] Funding Source: National Science Foundation
- BBSRC [BB/G008833/1] Funding Source: UKRI
- EPSRC [EP/J501426/1, EP/K03927X/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/G008833/1] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/J501426/1, GR/T03727/01, EP/K03927X/1] Funding Source: researchfish
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An ability to mimic the boundaries of biological compartments would improve our understanding of self-assembly and provide routes to new materials for the delivery of drugs and biologicals and the development of protocells. We show that short designed peptides can be combined to form unilamellar spheres approximately 100 nanometers in diameter. The design comprises two, noncovalent, heterodimeric and homotrimeric coiled-coil bundles. These are joined back to back to render two complementary hubs, which when mixed form hexagonal networks that close to form cages. This design strategy offers control over chemistry, self-assembly, reversibility, and size of such particles.
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