Journal
SCIENCE
Volume 340, Issue 6132, Pages 635-639Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1235487
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Funding
- European Research Council AdG Life-his-T
- Walter-Hitzig fellowship from the CCI [BMBF 01EO0803]
- Deutsche Forschungsgemeinschaft [DFG RO 4120/1-1]
- Marie Curie Intra European Fellowship
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek Veni grant [916.86.080]
- Leukemia and Lymphoma Society Career Development Fellowship
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Upon infection, antigen-specific CD8(+) T lymphocyte responses display a highly reproducible pattern of expansion and contraction that is thought to reflect a uniform behavior of individual cells. We tracked the progeny of individual mouse CD8(+) T cells by in vivo lineage tracing and demonstrated that, even for T cells bearing identical T cell receptors, both clonal expansion and differentiation patterns are heterogeneous. As a consequence, individual naive T lymphocytes contributed differentially to short-and long-term protection, as revealed by participation of their progeny during primary versus recall infections. The discordance in fate of individual naive T cells argues against asymmetric division as a singular driver of CD8(+) T cell heterogeneity and demonstrates that reproducibility of CD8(+) T cell responses is achieved through population averaging.
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