Journal
SCIENCE
Volume 342, Issue 6164, Pages 1364-1367Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1243357
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Funding
- National Science Foundation [DEB-1019989]
- BEACON Center for the Study of Evolution in Action [DBI-0939454]
- Hannah Chair Endowment at Michigan State University
- Division Of Environmental Biology
- Direct For Biological Sciences [1019989] Funding Source: National Science Foundation
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Experimental studies of evolution have increased greatly in number in recent years, stimulated by the growing power of genomic tools. However, organismal fitness remains the ultimate metric for interpreting these experiments, and the dynamics of fitness remain poorly understood over long time scales. Here, we examine fitness trajectories for 12 Escherichia coli populations during 50,000 generations. Mean fitness appears to increase without bound, consistent with a power law. We also derive this power-law relation theoretically by incorporating clonal interference and diminishing-returns epistasis into a dynamical model of changes in mean fitness over time.
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