Journal
SCIENCE
Volume 342, Issue 6159, Pages 747-749Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1242429
Keywords
-
Categories
Funding
- NIH [HG007036, HG006123, GM007197, MH084703]
- NSF [DGE-0638477]
- Howard Hughes Medical Institute
Ask authors/readers for more resources
Histone modifications are important markers of function and chromatin state, yet the DNA sequence elements that direct them to specific genomic locations are poorly understood. Here, we identify hundreds of quantitative trait loci, genome-wide, that affect histone modification or RNA polymerase II (Pol II) occupancy in Yoruba lymphoblastoid cell lines (LCLs). In many cases, the same variant is associated with quantitative changes in multiple histone marks and Pol II, as well as in deoxyribonuclease I sensitivity and nucleosome positioning. Transcription factor binding site polymorphisms are correlated overall with differences in local histone modification, and we identify specific transcription factors whose binding leads to histone modification in LCLs. Furthermore, variants that affect chromatin at distal regulatory sites frequently also direct changes in chromatin and gene expression at associated promoters.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available