Journal
SCIENCE
Volume 342, Issue 6163, Pages 1251-1254Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1244333
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Funding
- KU Leuven [OT/07/034, IDO/10/003]
- Research Foundation Flanders [G0331.08]
- European Research Council [ERC-2011-Stg-284101]
- Federal Research Action [IUAP/PAI P7/11]
- Queen Fabiola Foundation
- Wellcome Trust [098771/Z/12/Z, 101253/Z/13/Z, WT090961MA]
- Royal Society [101253/Z/13/Z]
- Wellcome Trust [098771/Z/12/Z, 101253/Z/13/Z] Funding Source: Wellcome Trust
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Dyslexia is a severe and persistent reading and spelling disorder caused by impairment in the ability to manipulate speech sounds. We combined functional magnetic resonance brain imaging with multivoxel pattern analysis and functional and structural connectivity analysis in an effort to disentangle whether dyslexics' phonological deficits are caused by poor quality of the phonetic representations or by difficulties in accessing intact phonetic representations. We found that phonetic representations are hosted bilaterally in primary and secondary auditory cortices and that their neural quality (in terms of robustness and distinctness) is intact in adults with dyslexia. However, the functional and structural connectivity between the bilateral auditory cortices and the left inferior frontal gyrus (a region involved in higher-level phonological processing) is significantly hampered in dyslexics, suggesting deficient access to otherwise intact phonetic representations.
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