Journal
SCIENCE
Volume 340, Issue 6133, Pages 701-706Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1233028
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Funding
- Medical Research Council [U105170648, U105181010]
- National Association for Colitis and Crohn's Disease [M/11/3]
- European Research Council [281627-IAI]
- NIH [AI068041-06]
- Burroughs Wellcome Fund Investigator in the Pathogenesis of Infectious Disease Award [1007845]
- Searle Foundation Scholars Program [05-F-114]
- Cancer Research Institute [CRI06-10]
- Crohn's and Colitis Foundation of America [R09928]
- Yale's W. W. Winchester Fund
- Medical Research Council [MC_U105181010, MC_U105170648] Funding Source: researchfish
- MRC [MC_U105170648, MC_U105181010] Funding Source: UKRI
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Our prevailing view of vertebrate host defense is strongly shaped by the notion of a specialized set of immune cells as sole guardians of antimicrobial resistance. Yet this view greatly underestimates a capacity for most cell lineages-the majority of which fall outside the traditional province of the immune system-to defend themselves against infection. This ancient and ubiquitous form of host protection is termed cell-autonomous immunity and operates across all three domains of life. Here, we discuss the organizing principles that govern cellular self-defense and how intracellular compartmentalization has shaped its activities to provide effective protection against a wide variety of microbial pathogens.
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