Journal
SCIENCE
Volume 340, Issue 6133, Pages 697-701Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1235771
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Funding
- NIAID NIH HHS [R01 AI081724] Funding Source: Medline
- NIGMS NIH HHS [T32 GM007753] Funding Source: Medline
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The pathogenesis of infection is a continuously evolving battle between the human host and the infecting microbe. The past decade has brought a burst of insights into the molecular mechanisms of innate immune responses to bacterial pathogens. In parallel, multiple specific mechanisms by which microorganisms subvert these host responses have been uncovered. This Review highlights recently characterized mechanisms by which bacterial pathogens avoid killing by innate host responses, including autophagy pathways and a proinflammatory cytokine transcriptional response, and by the manipulation of vesicular trafficking to avoid the toxicity of lysosomal enzymes.
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