Journal
SCIENCE
Volume 339, Issue 6117, Pages 332-335Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1226767
Keywords
-
Categories
Funding
- CNRS
- INSERM
- Agence Nationale de la Recherche (TIMMS)
- UPMC (Emergence program)
- Region Ile-de-France (NeRF)
- European Union
- Bettencourt Schueller Foundation
- Mission Interministerielle de Lutte contre la Dependance et la Toxicomanie
- Fondation pour la Recherche Medicale
Ask authors/readers for more resources
Repeated traumatic events induce long-lasting behavioral changes that are key to organism adaptation and that affect cognitive, emotional, and social behaviors. Rodents subjected to repeated instances of aggression develop enduring social aversion and increased anxiety. Such repeated aggressions trigger a stress response, resulting in glucocorticoid release and activation of the ascending dopamine (DA) system. We bred mice with selective inactivation of the gene encoding the glucocorticoid receptor (GR) along the DA pathway, and exposed them to repeated aggressions. GR in dopaminoceptive but not DA-releasing neurons specifically promoted social aversion as well as dopaminergic neurochemical and electrophysiological neuroadaptations. Anxiety and fear memories remained unaffected. Acute inhibition of the activity of DA-releasing neurons fully restored social interaction in socially defeated wild-type mice. Our data suggest a GR-dependent neuronal dichotomy for the regulation of emotional and social behaviors, and clearly implicate GR as a link between stress resiliency and dopaminergic tone.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available