Journal
SCIENCE
Volume 342, Issue 6161, Pages 976-979Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1244730
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Funding
- NWO VICI grant
- National Institute of Allergy and Infectious Diseases [HHSN266200700010C]
- NIH [DP1-OD000490-01]
- European Union [223498, 278976]
- Human Frontier Science Program [P0050/2008]
- Australian Government Department of Health and Aging
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The molecular basis of antigenic drift was determined for the hemagglutinin (HA) of human influenza A/H3N2 virus. From 1968 to 2003, antigenic change was caused mainly by single amino acid substitutions, which occurred at only seven positions in HA immediately adjacent to the receptor binding site. Most of these substitutions were involved in antigenic change more than once. Equivalent positions were responsible for the recent antigenic changes of influenza B and A/H1N1 viruses. Substitution of a single amino acid at one of these positions substantially changed the virus-specific antibody response in infected ferrets. These findings have potentially far-reaching consequences for understanding the evolutionary mechanisms that govern influenza viruses.
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