Journal
SCIENCE
Volume 342, Issue 6160, Pages 860-863Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1240667
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Funding
- Ghent University
- Interuniversity Attraction Poles Programme [IUAP P7/29]
- Belgian Science Policy Office
- Ghent University-Bijzonder Onderzoeksfonds
- Research Foundation-Flanders [G.029809, G.022.10N]
- Agency for Innovation by Science and Technology
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The quiescent center (QC) plays an essential role during root development by creating a microenvironment that preserves the stem cell fate of its surrounding cells. Despite being surrounded by highly mitotic active cells, QC cells self-renew at a low proliferation rate. Here, we identified the ERF115 transcription factor as a rate-limiting factor of QC cell division, acting as a transcriptional activator of the phytosulfokine PSK5 peptide hormone. ERF115 marks QC cell division but is restrained through proteolysis by the APC/C-CCS52A2 ubiquitin ligase, whereas QC proliferation is driven by brassinosteroid-dependent ERF115 expression. Together, these two antagonistic mechanisms delimit ERF115 activity, which is called upon when surrounding stem cells are damaged, revealing a cell cycle regulatory mechanism accounting for stem cell niche longevity.
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