Journal
SCIENCE
Volume 342, Issue 6161, Pages 946-+Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1242974
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Funding
- Agence Nationale de la Recherche [ANR-11-BSV3-0026]
- Medical Research Council UK [MR/K01207X1, MR/J001929/1]
- Wellcome Trust
- European Union [Health-2009-4.3.1-1, 242131]
- Agence Nationale de la Recherche (ANR) [ANR-11-BSV3-0026] Funding Source: Agence Nationale de la Recherche (ANR)
- Medical Research Council [MR/K01207X/1, MR/J001929/1] Funding Source: researchfish
- MRC [MR/K01207X/1, MR/J001929/1] Funding Source: UKRI
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In many mammalian tissues, mature differentiated cells are replaced by self-renewing stem cells, either continuously during homeostasis or in response to challenge and injury. For example, hematopoietic stem cells generate all mature blood cells, including monocytes, which have long been thought to be the major source of tissue macrophages. Recently, however, major macrophage populations were found to be derived from embryonic progenitors and to renew independently of hematopoietic stem cells. This process may not require progenitors, as mature macrophages can proliferate in response to specific stimuli indefinitely and without transformation or loss of functional differentiation. These findings suggest that macrophages are mature differentiated cells that may have a self-renewal potential similar to that of stem cells.
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