Journal
SCIENCE
Volume 341, Issue 6150, Pages 1113-1116Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1241210
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Funding
- CNRS
- INSERM
- Agence Nationale de la Recherche
- Fondation pour la Recherche Medicale
- European Research Council [268813]
- NIH [K99 HD073239, R01 GM093301]
- Danish Council for Independent Research, Natural Sciences [11-105446]
- European Research Council (ERC) [268813] Funding Source: European Research Council (ERC)
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Animal development is coupled with innate behaviors that maximize chances of survival. Here, we show that the prothoracicotropic hormone (PTTH), a neuropeptide that controls the developmental transition from juvenile stage to sexual maturation, also regulates light avoidance in Drosophila melanogaster larvae. PTTH, through its receptor Torso, acts on two light sensors-the Bolwig's organ and the peripheral class IV dendritic arborization neurons-to regulate light avoidance. We found that PTTH concomitantly promotes steroidogenesis and light avoidance at the end of larval stage, driving animals toward a darker environment to initiate the immobile maturation phase. Thus, PTTH controls the decisions of when and where animals undergo metamorphosis, optimizing conditions for adult development.
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