Journal
SCIENCE
Volume 336, Issue 6086, Pages 1262-1267Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1223813
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Funding
- Imperial College Healthcare Trust Biomedical Research Centre
- Bill and Melinda Gates Foundation
- UK Medical Research Council
- Wellcome Trust
- Fondation Merrieux
- UK Biotechnology and Biological Sciences Research Council
- Tate + Lyle
- Proctor and Gamble
- Ganeden
- Clasado
- Swedish Medical Research Council
- COMBINE
- EU
- Karolinska Institutet Inflammation Consortium
- Millennium Foundation Singapore
- National Cancer Centre Singapore
- Nanyang Technical University
- Agence Nationale de la Recherche
- European Framework Program FP7
- U.S. NIH [R01AA020212]
- Medical Research Council [G0801056B] Funding Source: researchfish
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The composition and activity of the gut microbiota codevelop with the host from birth and is subject to a complex interplay that depends on the host genome, nutrition, and life-style. The gut microbiota is involved in the regulation of multiple host metabolic pathways, giving rise to interactive host-microbiota metabolic, signaling, and immune-inflammatory axes that physiologically connect the gut, liver, muscle, and brain. A deeper understanding of these axes is a prerequisite for optimizing therapeutic strategies to manipulate the gut microbiota to combat disease and improve health.
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