Journal
SCIENCE
Volume 335, Issue 6070, Pages 831-834Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1214081
Keywords
-
Categories
Funding
- Burroughs Wellcome Fund
- Wyss Technology Development Fellowship
- Life Sciences Research Foundation
- Grants-in-Aid for Scientific Research [23770216] Funding Source: KAKEN
Ask authors/readers for more resources
We describe an autonomous DNA nanorobot capable of transporting molecular payloads to cells, sensing cell surface inputs for conditional, triggered activation, and reconfiguring its structure for payload delivery. The device can be loaded with a variety of materials in a highly organized fashion and is controlled by an aptamer-encoded logic gate, enabling it to respond to a wide array of cues. We implemented several different logical AND gates and demonstrate their efficacy in selective regulation of nanorobot function. As a proof of principle, nanorobots loaded with combinations of antibody fragments were used in two different types of cell-signaling stimulation in tissue culture. Our prototype could inspire new designs with different selectivities and biologically active payloads for cell-targeting tasks.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available