Journal
SCIENCE
Volume 338, Issue 6111, Pages 1177-1183Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1227268
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Funding
- Office of Naval Research (ONR) Young Investigator Program award [N000141110914]
- ONR grant [N000141010827, N000014091118, N000141010241]
- Army Research Office [W911NF1210238]
- NSF [CCF1054898]
- NIH [1DP2OD007292, 1DP2OD004641]
- Wyss Institute Faculty Startup Fund
- Wyss Institute Faculty Grant
- U.S. Department of Defense (DOD) [W911NF1210238] Funding Source: U.S. Department of Defense (DOD)
- Division of Computing and Communication Foundations
- Direct For Computer & Info Scie & Enginr [1054898] Funding Source: National Science Foundation
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We describe a simple and robust method to construct complex three-dimensional (3D) structures by using short synthetic DNA strands that we call DNA bricks. In one-step annealing reactions, bricks with hundreds of distinct sequences self-assemble into prescribed 3D shapes. Each 32-nucleotide brick is a modular component; it binds to four local neighbors and can be removed or added independently. Each 8-base pair interaction between bricks defines a voxel with dimensions of 2.5 by 2.5 by 2.7 nanometers, and a master brick collection defines a molecular canvas with dimensions of 10 by 10 by 10 voxels. By selecting subsets of bricks from this canvas, we constructed a panel of 102 distinct shapes exhibiting sophisticated surface features, as well as intricate interior cavities and tunnels.
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