Journal
SCIENCE
Volume 338, Issue 6114, Pages 1599-1603Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1229765
Keywords
-
Categories
Funding
- O'Donnell Foundation Fellow of the Life Sciences Research Foundation
- NIH Pathway [1K99HL114738]
- NIH [HL100401-01]
- Donald W. Reynolds Center for Clinical Cardiovascular Research
- American Heart Association
- Jon Holden DeHaan Foundation
- Leducq Foundation
- Robert A. Welch Foundation [1-0025]
Ask authors/readers for more resources
The epicardium encapsulates the heart and functions as a source of multipotent progenitor cells and paracrine factors essential for cardiac development and repair. Injury of the adult heart results in reactivation of a developmental gene program in the epicardium, but the transcriptional basis of epicardial gene expression has not been delineated. We established a mouse embryonic heart organ culture and gene expression system that facilitated the identification of epicardial enhancers activated during heart development and injury. Epicardial activation of these enhancers depends on a combinatorial transcriptional code centered on CCAAT/enhancer binding protein (C/EBP) transcription factors. Disruption of C/EBP signaling in the adult epicardium reduced injury-induced neutrophil infiltration and improved cardiac function. These findings reveal a transcriptional basis for epicardial activation and heart injury, providing a platform for enhancing cardiac regeneration.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available