Journal
SCIENCE
Volume 335, Issue 6075, Pages 1510-1513Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1207615
Keywords
-
Categories
Funding
- Centre National de la Recherche Scientifique
- Institut National de la Sante et de la Recherche Medicale
- Fondation pour la Recherche sur le Cerveau
- Conseil Regional d'Aquitaine
- Ministere de l'Enseignement superieur et de la Recherche
- University of Bordeaux
Ask authors/readers for more resources
Posttraumatic stress disorder (PTSD) is characterized by a hypermnesia of the trauma and by a memory impairment that decreases the ability to restrict fear to the appropriate context. Infusion of glucocorticoids in the hippocampus after fear conditioning induces PTSD-like memory impairments and an altered pattern of neural activation in the hippocampal-amygdalar circuit. Mice become unable to identify the context as the correct predictor of the threat and show fear responses to a discrete cue not predicting the threat in normal conditions. These data demonstrate PTSD-like memory impairments in rodents and identify a potential pathophysiological mechanism of this condition.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available