Journal
SCIENCE
Volume 336, Issue 6082, Pages 724-727Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1221071
Keywords
-
Categories
Funding
- L'Agence Nationale de la Recherche-MorphoDro [ARC-4830]
- European Research Council-CePoDro
- Fondation pour la Recherche Medicale
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek-Rubicon
Ask authors/readers for more resources
During animal development, several planar cell polarity (PCP) pathways control tissue shape by coordinating collective cell behavior. Here, we characterize by means of multiscale imaging epithelium morphogenesis in the Drosophila dorsal thorax and show how the Fat/Dachsous/Four-jointed PCP pathway controls morphogenesis. We found that the proto-cadherin Dachsous is polarized within a domain of its tissue-wide expression gradient. Furthermore, Dachsous polarizes the myosin Dachs, which in turn promotes anisotropy of junction tension. By combining physical modeling with quantitative image analyses, we determined that this tension anisotropy defines the pattern of local tissue contraction that contributes to shaping the epithelium mainly via oriented cell rearrangements. Our results establish how tissue planar polarization coordinates the local changes of cell mechanical properties to control tissue morphogenesis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available