Journal
SCIENCE
Volume 338, Issue 6104, Pages 257-260Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1224143
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Funding
- Fonds zur Forderung der wissenschaftlichen Forschung (FWF)
- Deutsche Forschungsgemeinschaft (DFG) [I930-B20]
- Austrian Science Fund (FWF) [I930] Funding Source: Austrian Science Fund (FWF)
- Austrian Science Fund (FWF) [I 930] Funding Source: researchfish
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Contractile actomyosin rings drive various fundamental morphogenetic processes ranging from cytokinesis to wound healing. Actomyosin rings are generally thought to function by circumferential contraction. Here, we show that the spreading of the enveloping cell layer (EVL) over the yolk cell during zebrafish gastrulation is driven by a contractile actomyosin ring. In contrast to previous suggestions, we find that this ring functions not only by circumferential contraction but also by a flow-friction mechanism. This generates a pulling force through resistance against retrograde actomyosin flow. EVL spreading proceeds normally in situations where circumferential contraction is unproductive, indicating that the flow-friction mechanism is sufficient. Thus, actomyosin rings can function in epithelial morphogenesis through a combination of cable-constriction and flow-friction mechanisms.
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