Journal
SCIENCE
Volume 337, Issue 6095, Pages 735-737Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1223154
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Funding
- NIH [NS34994, MH54671, NS074015]
- Human Frontier Science Program
- J. D. McDonnell Foundation
- European Community [254780]
- Rosztoczy Foundation
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Many neurological and psychiatric diseases are associated with clinically detectable, altered brain dynamics. The aberrant brain activity, in principle, can be restored through electrical stimulation. In epilepsies, abnormal patterns emerge intermittently, and therefore, a closed-loop feedback brain control that leaves other aspects of brain functions unaffected is desirable. Here, we demonstrate that seizure-triggered, feedback transcranial electrical stimulation (TES) can dramatically reduce spike-and-wave episodes in a rodent model of generalized epilepsy. Closed-loop TES can be an effective clinical tool to reduce pathological brain patterns in drug-resistant patients.
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