Journal
SCIENCE
Volume 338, Issue 6105, Pages 374-379Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1227721
Keywords
-
Categories
Funding
- Wenner-Gren Foundation
- Intramural Research Program of the National Institute on Aging
- NIH
- U.S. Department of Health and Human Services [Z01 AG000932-04]
- Medical Research Council of South Africa
- National Health Laboratory Service
- STINT
- Swedish Research Council
- Erik Philip Sorensen Foundation
Ask authors/readers for more resources
The history of click-speaking Khoe-San, and African populations in general, remains poorly understood. We genotyped similar to 2.3 million single-nucleotide polymorphisms in 220 southern Africans and found that the Khoe-San diverged from other populations >= 100,000 years ago, but population structure within the Khoe-San dated back to about 35,000 years ago. Genetic variation in various sub-Saharan populations did not localize the origin of modern humans to a single geographic region within Africa; instead, it indicated a history of admixture and stratification. We found evidence of adaptation targeting muscle function and immune response; potential adaptive introgression of protection from ultraviolet light; and selection predating modern human diversification, involving skeletal and neurological development. These new findings illustrate the importance of African genomic diversity in understanding human evolutionary history.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available