Journal
SCIENCE
Volume 335, Issue 6072, Pages 1092-1096Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1214678
Keywords
-
Categories
Funding
- U.K. Biotechnology and Biological Sciences Research Council (BBSRC)
- BBSRC [BB/F005997/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BBS/E/J/00000152, BB/F005997/1] Funding Source: researchfish
Ask authors/readers for more resources
A major challenge in biology is to understand how buds comprising a few cells can give rise to complex plant and animal appendages like leaves or limbs. We address this problem through a combination of time-lapse imaging, clonal analysis, and computational modeling. We arrive at a model that shows how leaf shape can arise through feedback between early patterns of oriented growth and tissue deformation. Experimental tests through partial leaf ablation support this model and allow reevaluation of previous experimental studies. Our model allows a range of observed leaf shapes to be generated and predicts observed clone patterns in different species. Thus, our experimentally validated model may underlie the development and evolution of diverse organ shapes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available