Journal
SCIENCE
Volume 336, Issue 6086, Pages 1317-1321Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1220030
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Funding
- NIH, National Cancer Institute [P30CA016087]
- NIH [RO1AI062980]
- American Cancer Society [RSG-10-158-01-LIB]
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The chemokine-mediated recruitment of effector T cells to sites of inflammation is a central feature of the immune response. The extent to which chemokine expression levels are limited by the intrinsic developmental characteristics of a tissue has remained unexplored. We show in mice that effector T cells cannot accumulate within the decidua, the specialized stromal tissue encapsulating the fetus and placenta. Impaired accumulation was in part attributable to the epigenetic silencing of key T cell-attracting inflammatory chemokine genes in decidual stromal cells, as evidenced by promoter accrual of repressive histone marks. These findings give insight into mechanisms of fetomaternal immune tolerance, as well as reveal the epigenetic modification of tissue stromal cells as a modality for limiting effector T cell trafficking.
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