Journal
SCIENCE
Volume 335, Issue 6076, Pages 1624-1628Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1215101
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Funding
- U.K. Biotechnology and Biological Sciences Research Council (BBSRC) [F005490]
- Medical Research Council [G0400598]
- Wellcome Trust [064413, 095667]
- European Research Council (ERC)
- Janos Bolyai Scholarship
- BBSRC [BB/F005490/1] Funding Source: UKRI
- MRC [G0400598] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/F005490/1] Funding Source: researchfish
- Medical Research Council [G0400598] Funding Source: researchfish
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Electrically coupled inhibitory interneurons dynamically control network excitability, yet little is known about how chemical and electrical synapses regulate their activity. Using two-photon glutamate uncaging and dendritic patch-clamp recordings, we found that the dendrites of cerebellar Golgi interneurons acted as passive cables. They conferred distance-dependent sublinear synaptic integration and weakened distal excitatory inputs. Gap junctions were present at a higher density on distal dendrites and contributed substantially to membrane conductance. Depolarization of one Golgi cell increased firing in its neighbors, and inclusion of dendritic gap junctions in interneuron network models enabled distal excitatory synapses to drive network activity more effectively. Our results suggest that dendritic gap junctions counteract sublinear dendritic integration by enabling excitatory synaptic charge to spread into the dendrites of neighboring inhibitory interneurons.
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