Journal
SCIENCE
Volume 339, Issue 6115, Pages 70-74Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1227622
Keywords
-
Categories
Funding
- NIH [R01 MH094705]
- Japan Science and Technology Agency
- Brain and Behavior Research Foundation (NARSAD)
- Patterson Foundation
- Simons Foundation
- NARSAD
Ask authors/readers for more resources
Diverse gamma-aminobutyric acid-releasing interneurons regulate the functional organization of cortical circuits and derive from multiple embryonic sources. It remains unclear to what extent embryonic origin influences interneuron specification and cortical integration because of difficulties in tracking defined cell types. Here, we followed the developmental trajectory of chandelier cells (ChCs), the most distinct interneurons that innervate the axon initial segment of pyramidal neurons and control action potential initiation. ChCs mainly derive from the ventral germinal zone of the lateral ventricle during late gestation and require the homeodomain protein Nkx2.1 for their specification. They migrate with stereotyped routes and schedule and achieve specific laminar distribution in the cortex. The developmental specification of this bona fide interneuron type likely contributes to the assembly of a cortical circuit motif.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available