Journal
RSC ADVANCES
Volume 5, Issue 25, Pages 19620-19623Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ra15414b
Keywords
-
Categories
Funding
- National Science and Technology Major Project in China [2011ZX11401-026]
Ask authors/readers for more resources
Celastrol is a natural triterpenoid which possesses diverse pharmacological activities including potent antitumor activity. Previously, we reported a C(6)-modified celastrol derivative NST001A which possesses cytotoxic activity against Colon 205 cells with a 60 nM IC50 value. To further explore the structure activity relationships, a new class of C(6)-indole substituted celastrol derivatives were designed and synthesized. Biological evaluation of these compounds includes their cytotoxic activity against human hepatocellular carcinoma Bel7402 and human glioblastoma cell line H4. Among all these semisynthetic analogues, compound 4f and 4h displayed excellent in vitro antiproliferative activities against Bel7402 cancer cells (IC50 = 0.02 mu M and 0.01 mu M, respectively).
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available