Journal
SCIENCE
Volume 339, Issue 6118, Pages 456-460Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1230835
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Funding
- China National Genebank at Shenzhen
- CSIRO
- Australian Research Council [FT110100234]
- State Key Program for Basic Research [2011CB504701]
- National Natural Science Foundation of China [81290341]
- Defense Threat Reduction Agency of the USA
- Australian Research Council [FT110100234] Funding Source: Australian Research Council
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Bats are the only mammals capable of sustained flight and are notorious reservoir hosts for some of the world's most highly pathogenic viruses, including Nipah, Hendra, Ebola, and severe acute respiratory syndrome (SARS). To identify genetic changes associated with the development of bat-specific traits, we performed whole-genome sequencing and comparative analyses of two distantly related species, fruit bat Pteropus alecto and insectivorous bat Myotis davidii. We discovered an unexpected concentration of positively selected genes in the DNA damage checkpoint and nuclear factor kappa B pathways that may be related to the origin of flight, as well as expansion and contraction of important gene families. Comparison of bat genomes with other mammalian species has provided new insights into bat biology and evolution.
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