Journal
SCIENCE
Volume 336, Issue 6078, Pages 187-191Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1215478
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Funding
- Max Planck Society
- European Research Council (ERC) under the European Communities [207634]
- Japan Society for the Promotion of Science
- CSIC [JAEDOC014]
- European Social Fund
- Ministerio de Ciencia e Innovacion (Spain) through MOSAICO
- European Research Council (ERC) [207634] Funding Source: European Research Council (ERC)
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Computational approaches are breaking new ground in understanding how embryos form. Here, we discuss recent studies that couple precise measurements in the embryo with appropriately matched modeling and computational methods to investigate classic embryonic patterning strategies. We include signaling gradients, activator-inhibitor systems, and coupled oscillators, as well as emerging paradigms such as tissue deformation. Parallel progress in theory and experiment will play an increasingly central role in deciphering developmental patterning.
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