Journal
SCIENCE
Volume 333, Issue 6039, Pages 238-242Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1203165
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Funding
- Swedish Research Council
- Swedish Cancer Society
- Tobias Stiftelsen
- Hjarnfonden
- Knut och Alice Wallenbergs Stiftelse
- Swedish Agency for Innovation Systems
- European Research Council [ERC-AG/250297-RAS AHEAD]
- Foundation for Science and Technology, Portuguese government [SFRH/BD/63164/2009]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/63164/2009] Funding Source: FCT
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There is limited regeneration of lost tissue after central nervous system injury, and the lesion is sealed with a scar. The role of the scar, which often is referred to as the glial scar because of its abundance of astrocytes, is complex and has been discussed for more than a century. Here we show that a specific pericyte subtype gives rise to scar-forming stromal cells, which outnumber astrocytes, in the injured spinal cord. Blocking the generation of progeny by this pericyte subtype results in failure to seal the injured tissue. The formation of connective tissue is common to many injuries and pathologies, and here we demonstrate a cellular origin of fibrosis.
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