Journal
SCIENCE
Volume 333, Issue 6048, Pages 1456-1458Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1202529
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Funding
- EMBL
- Foundation Cenci Bolognetti
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Microglia are highly motile phagocytic cells that infiltrate and take up residence in the developing brain, where they are thought to provide a surveillance and scavenging function. However, although microglia have been shown to engulf and clear damaged cellular debris after brain insult, it remains less clear what role microglia play in the uninjured brain. Here, we show that microglia actively engulf synaptic material and play a major role in synaptic pruning during postnatal development in mice. These findings link microglia surveillance to synaptic maturation and suggest that deficits in microglia function may contribute to synaptic abnormalities seen in some neurodevelopmental disorders.
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