Journal
SCIENCE
Volume 334, Issue 6061, Pages 1415-1420Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1210125
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Funding
- NIH [R01-MH078821, P50-MH58880]
- RIKEN Brain Science Institute
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Associating temporally discontinuous elements is crucial for the formation of episodic and working memories that depend on the hippocampal-entorhinal network. However, the neural circuits subserving these associations have remained unknown. The layer III inputs of the entorhinal cortex to the hippocampus may contribute to this process. To test this hypothesis, we generated a transgenic mouse in which these inputs are specifically inhibited. The mutant mice displayed significant impairments in spatial working-memory tasks and in the encoding phase of trace fear-conditioning. These results indicate a critical role of the entorhinal cortex layer III inputs to the hippocampus in temporal association memory.
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