Journal
SCIENCE
Volume 331, Issue 6023, Pages 1433-1436Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1198914
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Funding
- NSF [DEB1019989]
- Defense Advanced Research Projects Agency [HR0011-09-1-0055]
- NIH [K99GM087550]
- McDonnell Foundation [220020174]
- Direct For Biological Sciences
- Division Of Environmental Biology [0844355] Funding Source: National Science Foundation
- Division Of Environmental Biology
- Direct For Biological Sciences [1019989] Funding Source: National Science Foundation
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In theory, competition between asexual lineages can lead to second-order selection for greater evolutionary potential. To test this hypothesis, we revived a frozen population of Escherichia coli from a long-term evolution experiment and compared the fitness and ultimate fates of four genetically distinct clones. Surprisingly, two clones with beneficial mutations that would eventually take over the population had significantly lower competitive fitness than two clones with mutations that later went extinct. By replaying evolution many times from these clones, we showed that the eventual winners likely prevailed because they had greater potential for further adaptation. Genetic interactions that reduce the benefit of certain regulatory mutations in the eventual losers appear to explain, at least in part, why they were outcompeted.
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