Journal
SCIENCE
Volume 333, Issue 6047, Pages 1248-1252Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1206843
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Funding
- National Institutes of Health
- Howard Hughes Medical Institute
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Synthetic biology is an emerging field focused on engineering biomolecular systems and cellular capabilities for a variety of applications. Substantial progress began a little over a decade ago with the creation of synthetic gene networks inspired by electrical engineering. Since then, the field has designed and built increasingly complex circuits and constructs and begun to use these systems in a variety of settings, including the clinic. These efforts include the development of synthetic biology therapies for the treatment of infectious diseases and cancer, as well as approaches in vaccine development, microbiome engineering, cell therapy, and regenerative medicine. Here, we highlight advances in the biomedical application of synthetic biology and discuss the field's clinical potential.
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