Journal
SCIENCE
Volume 332, Issue 6026, Pages 247-251Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1201678
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Funding
- Kavli Institute
- NAAR/Autism Speaks fellowship
- [MH07907]
- [GM56203]
- [GM41890]
- [K99CA133245]
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Axon-dendrite polarization is crucial for neural network wiring and information processing in the brain. Polarization begins with the transformation of a single neurite into an axon and its subsequent rapid extension, which requires coordination of cellular energy status to allow for transport of building materials to support axon growth. We found that activation of the energy-sensing adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) pathway suppressed axon initiation and neuronal polarization. Phosphorylation of the kinesin light chain of the Kif5 motor protein by AMPK disrupted the association of the motor with phosphatidylinositol 3-kinase (PI3K), preventing PI3K targeting to the axonal tip and inhibiting polarization and axon growth.
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