Journal
SCIENCE
Volume 334, Issue 6059, Pages 1114-1117Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1213920
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Funding
- Marie-Curie Actions for an International Outgoing Fellowship
- NIH General Medical Sciences (NIHGMS) [NIHGMS R01 01 GM093213-01]
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Serendipity has long been a welcome yet elusive phenomenon in the advancement of chemistry. We sought to exploit serendipity as a means of rapidly identifying unanticipated chemical transformations. By using a high-throughput, automated workflow and evaluating a large number of random reactions, we have discovered a photoredox-catalyzed C-H arylation reaction for the construction of benzylic amines, an important structural motif within pharmaceutical compounds that is not readily accessed via simple substrates. The mechanism directly couples tertiary amines with cyanoaromatics by using mild and operationally trivial conditions.
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