Journal
SCIENCE
Volume 333, Issue 6039, Pages 209-213Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1204183
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Funding
- NIH [RC1-GM091161]
- Mitsubishi Chemical Corporation
- NSF [CHE-1041934]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1041934] Funding Source: National Science Foundation
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Aromatic molecules are key constituents of many pharmaceuticals, electronic materials, and commodity plastics. The utility of these molecules directly reflects the identity and pattern of substituents on the aromatic ring. Here, we report a palladium(II) catalyst system, incorporating an unconventional ortho-dimethylaminopyridine ligand, for the conversion of substituted cyclohexanones to the corresponding phenols. The reaction proceeds via successive dehydrogenation of two saturated carbon-carbon bonds of the six-membered ring and uses molecular oxygen as the hydrogen acceptor. This reactivity demonstrates a versatile and efficient strategy for the synthesis of substituted aromatic molecules with fundamentally different selectivity constraints from the numerous known synthetic methods that rely on substitution of a preexisting aromatic ring.
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