Journal
SCIENCE
Volume 333, Issue 6047, Pages 1244-1248Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1207084
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Funding
- NIH [5R01GM086793, 5R01GM079771, P50GM068763]
- NSF [0644463]
- Packard Fellowship
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [0644463] Funding Source: National Science Foundation
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A major goal of synthetic biology is to develop a deeper understanding of biological design principles from the bottom up, by building circuits and studying their behavior in cells. Investigators initially sought to design circuits from scratch that functioned as independently as possible from the underlying cellular system. More recently, researchers have begun to develop a new generation of synthetic circuits that integrate more closely with endogenous cellular processes. These approaches are providing fundamental insights into the regulatory architecture, dynamics, and evolution of genetic circuits and enabling new levels of control across diverse biological systems.
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